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Active Ingredient: Orlistat

Orlistat is a lipase inhibitor used for helping you to lose your weight and also keep it from returning.

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Orlistat weight loss

The drug Orlistat is a popular way to lose weight. An indication for its use is obesity, in which the body mass index is several times higher than normal values. The drug reduces weight and prevents weight gain in the future. Such an effect is due to the fact that fat is not absorbed by the body and is excreted along with feces. Orlistat is not used to lose a few pounds. This medicine with serious indications, a number of side effects and restrictions to use.

The active ingredient in the composition of the drug is the substance of the same name. The medicine is used to treat obesity and prevent the risk of weight gain. Orlistat for weight loss is effective, because it belongs to the category of inhibitors of gastrointestinal lipases. These are enzymes that process fats. The result is that they are not stored by the body as a reserve, but are eliminated during bowel emptying. Manufacturers say that only taking Orlistat will not help lose weight. The drug only improves the results of diet and exercise.

The general indication for the use of Orlistat is the need to lose weight, but not a couple of extra pounds. Doctors prescribe this drug to patients with obesity of various degrees. Against the background of taking the medication, they still need to follow a diet and play sports. Only Orlistat for weight loss will have high efficiency. Specific indications for treatment with this medication are:

  • obesity with a body mass index of more than 30 kg / m2;
  • obesity with a body mass index of over 27 kg / m2 and associated risk factors such as diabetes, dyslipidemia, arterial hypertension;
  • reducing the risk of re-gaining body weight after successful weight loss.

How does Orlistat work?

The main effect of orlistat is inhibition of gastrointestinal lipases. These are enzymes that break down fats in the body. As a result, the breakdown of the latter into fatty acids and monoglycerides becomes impossible. Because of this, the components of fat are not absorbed into the bloodstream, which leads to a shortage of calories in the body. These effects ensure the use of your own fat reserves, deposited in excess.

The therapeutic dose of the drug blocks up to 30% of incoming fat. It shows activity without producing a systemic effect on the organism, because it does not penetrate into the blood. Metabolism occurs in the intestinal walls, where metabolites are formed. The drug is completely eliminated from the body after 5 days. With prolonged use, a slight effect is observed on the balance of trace elements such as calcium, iron, magnesium, zinc, phosphorus. The negative effect of the agent does not apply to:

  • composition and properties of bile;
  • acidity of gastric juice;
  • the speed of advance of the food bolus along the digestive tract.

According to physicians, taking medicine for a year and following a diet, you can get rid of more than 3.4 kilograms than just by limiting nutrition. The same results are obtained when using a low-carb diet. It provides an opportunity not to use supplements and not to restrict the intake of healthy fats too much, because it is harmful for the body. For this reason, the decision on the admission of Orlistat is made individually.

How to get best results from orlistat?

The medication is intended for oral administration. It is taken inside strictly according to the instructions. The dosage for an adult is 120 mg (one capsule). Drug Administration Rules:

  • the capsule is taken daily with meals or one hour after the meal;
  • per day you can consume no more than 3 capsules;
  • if the food on some day, the food contains little fat, then you can not take Orlistat for weight loss.

During the first six months, body weight should be reduced by 10%. If this does not happen, then it is necessary to stop taking the medicine and consult a doctor for more accurate diagnosis and prescription of another drug. It is necessary to use medicine against the background of moderate hypocaloric nutrition. The nutritional value of the diet should be calculated taking into account the weight and mode of life of the patient. On average, it is reduced by 500-800 kcal to ensure a shortage of energy. The fat content should not exceed 30%. The diet should enrich:

  • fruits;
  • greens;
  • seafood;
  • natural juices;
  • vegetables;
  • lean meat and fish.

The active ingredient of the drug lowers the degree of absorption of fat-soluble vitamins. For this reason, during treatment it is necessary to ensure their normal intake. This is achieved by taking multivitamin complexes that contain these fat-soluble vitamins. They are consumed 2 hours before or 2 hours after taking Orlistat capsules.

Orlistat during pregnancy and in childhood

The drug is allowed in childhood, but only after 12 years of age. The period of pregnancy and breastfeeding are absolute contraindications to the use of Orlistat for weight loss. During lactation, the drug is prohibited, since there is no information about whether the active substance is secreted into breast milk. Well controlled and adequate studies of the use of this drug in pregnant women have not been conducted.

During pregnancy, the drug is contraindicated because a decrease in body weight during this period does not bear the potential benefit to a woman. In addition, a negative effect on the fetus is possible. So that a woman does not suffer from overweight during this period, she is recommended to have a minimal increase in body weight, and not to decrease it after a sharp set. If pregnancy occurs while taking the drug, the medication should be canceled.

Orlistat side effects

Orlistat for weight loss is effective, but can affect the activity of the gastrointestinal tract. In most cases, the cause of adverse reactions is eating too fatty foods. To avoid negative reactions, you must adhere to a balanced diet with a low calorie content and a daily fat content of about 30% of the norm. Among the side effects on the digestive tract are:
  • fecal incontinence;
  • “Fat” stools;
  • flatulence;
  • imperative urge to stool;
  • oily discharge of their rectum;
  • frequent defecation.
Another group of adverse reactions are deviations in the nervous system, which manifest themselves in the first 1-4 weeks of the use of drugs. In this case, there are dizziness, sleep problems, headache, anxiety. Due to impaired absorption of fats, intestinal steatorrhea and deficiency of fat-soluble vitamins are sometimes possible. In some patients, the content of oxalates in the urine may increase. In the post-registration period, there have been cases of serious side effects, such as acute liver failure. In some cases, it led to the need for liver transplantation and even death. The doctor in the appointment of Orlistat for weight loss should warn the patient about the need to seek help for the development of liver disorders, which manifest themselves:
  • anorexia;
  • pruritus;
  • discoloration of feces and urine;
  • jaundice;
  • pain in the right hypochondrium.

Orlistat before and after

Below are the results of using Orlistat:

1.Use of the Orlistat for 3 months.

orlistat before and after

2.Use of the Orlistat for 7 months.

orlistat before and after

3.Use of the Orlistat for 2 years

orlistat before and after
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